{"id":5251,"date":"2020-07-14T10:45:00","date_gmt":"2020-07-14T10:45:00","guid":{"rendered":"https:\/\/aviancetechnologies.com\/blog\/blog\/babies-mysterious-resilience-to-coronavirus-intrigues-scientists\/"},"modified":"2020-07-14T10:45:00","modified_gmt":"2020-07-14T10:45:00","slug":"babies-mysterious-resilience-to-coronavirus-intrigues-scientists","status":"publish","type":"post","link":"https:\/\/aviancetechnologies.com\/blog\/babies-mysterious-resilience-to-coronavirus-intrigues-scientists\/","title":{"rendered":"Babies&#8217; Mysterious Resilience to Coronavirus Intrigues Scientists"},"content":{"rendered":"<p>\u00a0\u00a0 <\/p>\n<p>[responsivevoice_button rate=&#8221;1\u2033 pitch=&#8221;1.2\u2033 volume=&#8221;0.8\u2033 voice=&#8221;US English Female&#8221; buttontext=&#8221;Story in Audio&#8221;]<\/p>\n<h2>Babies&#8217; Mysterious Resilience to Coronavirus Intrigues Scientists<\/h2>\n<p><img decoding=\"async\" src=\"https:\/\/static.scientificamerican.com\/sciam\/cache\/file\/7EC5638B-20EA-4239-8EA1A525A823EBD8_source.jpg\" \/><\/p>\n<div>\n<p>As the new coronavirus continues to burn through populations, studies are beginning to shed light on its impact on infants. And so far the findings have been promising for parents and researchers alike.<\/p>\n<p>The initial data suggest that infants make up a small fraction of people who have tested positive for COVID-19. A Centers for Disease Control and Prevention study released in April reported 398 infections in children under one year of age\u2014roughly 0.3 percent of all U.S. cases at that time for which age was known. In addition, most of these cases appear mild in nature: a recent review published in the <em>Italian Journal of Pediatrics<\/em> that looked at infants up to the age of six months found that those who were infected would typically exhibit only a slight cough, runny nose or fever, which disappeared in a week or so. Other studies have suggested similar minor reactions. The question is: Why?<\/p>\n<p>One of the favored hypotheses focuses on how easily the new coronavirus can gain access to the body\u2019s tissues. Infection occurs when particles of the virus, SARS-CoV-2, enter human cells through a receptor called ACE2 and hijack those cells\u2019 machinery to make copies of themselves. These copies then invade new cells. The thinking is that infant cells have only a few ACE2 receptors, whereas those of an elderly person might harbor thousands. With fewer available points of entry in a baby, it could be harder for the virus to break in. Alternatively\u2014and perhaps counterintuitively\u2014an infant\u2019s immune system might simply be too immature to attack SARS-CoV-2. Given that most of the damage in severe COVID-19 cases seems to be caused by strong immune responses, that immaturity may work in babies\u2019 favor.<\/p>\n<p>The latter possibility could even explain a subtlety within the data: although infants appear resilient to COVID-19, they might be at a marginally higher risk than older children. Early data from China suggested that 10.6 percent of infected children younger than one had severe or critical illness\u2014a rate that decreased dramatically with age. \u201cIt\u2019s a dance that takes place between the virus and our own immune system,\u201d says Rana Chakraborty, a pediatric infectious disease specialist at the Mayo Clinic. If the body\u2019s defenses react too little, the virus will be able to take over. An overreaction can be equally deadly, however. So children older than about one year of age might be in a sweet spot between infants, whose immune system has not yet fully kicked in, and adults, whose defenses are sometimes overzealous.<\/p>\n<p>Indeed, the April CDC study similarly found that infants younger than one account for the highest percentage of hospitalizations among young children. But Leena B. Mithal, a pediatric infectious disease specialist at Northwestern University, argues that this trend could simply be because all newborns taken to a hospital routinely undergo a full examination to ensure they do not have an underlying bacterial infection\u2014a process that can take days. She conducted a study involving 18 infants younger than 90 days who tested positive for SARS-CoV-2 at the Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago and found that although half of the babies were hospitalized, none required intensive care. \u201cI think that is reassuring, that young infants actually may not be at a specifically higher risk of severe and critical illness, as we initially were worried about,\u201d Mithal says.<\/p>\n<p>Although some of the details still need to be teased out, it is clear that infants are uniquely resilient to COVID-19\u2014a finding that could aid in treatment development efforts. Scientists have already identified drugs that block certain inflammatory pathways in the body, and several are in clinical trials in COVID-19 patients. Another possibility is that drugs that target the ACE2 receptor could be the key to a vaccine or treatment.<\/p>\n<p>Scientists have also hypothesized that children are more likely to have recently been infected with other coronaviruses, which could provide cross-protective antibodies. Or maybe the answer comes down to the fact that infants and older children often do not yet have underlying health problems. \u201cThat would give them a better head start\u2014at least biologically,\u201d says Aimee Ferraro, a senior core faculty member at the School of Health Sciences at Walden University.<\/p>\n<p>The high rate of mild cases in infected children seems promising\u2014both for researchers who would like to target treatment and anxious parents. But the data remain limited, and experts continue to be cautious. It is important to remember that we simply do not know the long-term consequences of COVID-19, Ferraro says. This ignorance is evident in a number of cases in which youngsters initially became mildly sick with the disease and later developed a potentially life-threatening condition known as multisystem inflammatory syndrome in children, or MIS-C, in which various organs become inflamed. Although this phenomenon has mostly occurred in children older than one, Mithal argues that it is too early to tell whether infants can develop it or not.<\/p>\n<p>\u201cParents should be aware that it&#8217;s important to protect children\u2014not [just] from the infection itself\u2014because it\u2019s mild\u2014but also from this postinflammatory syndrome,\u201d\u00a0says Asif Noor, a clinical assistant professor of pediatrics at New York University, who specializes in infectious diseases among children. With that warning in mind, he advises that parents should limit visitors during a baby\u2019s first few months and ask that everyone\u2014even those who are asymptomatic\u2014stand at least six feet away from the newborn. Although informing grandparents that they cannot hold their new grandchild might be heartbreaking, he argues that doing so is undoubtedly for the best. And Ferraro notes that cases among newborns might appear lower for the sheer reason that many have been shielded from the world\u2014family members included\u2014since the beginning of the pandemic. \u201cI think this is a new normal,\u201d Noor says.<\/p>\n<p><em>Read more about the coronavirus outbreak <\/em><em>from <\/em>Scientific American<em> here<\/em><em>. And read coverage from our international network of magazines here.<\/em><\/p>\n<\/div>\n<div class=\"post-item-metadata entry-meta\">\n<p class=\"has-background has-very-light-gray-background-color\">Disclaimer: Content may be edited for style and length.\u00a0<a class=\"newsium-categories category-color-1\" href=\"http:\/\/rss.sciam.com\/~r\/ScientificAmerican-News\/~3\/WpBLgxNeqgc\/\" target=\"_blank\" rel=\"noopener noreferrer\">Story Source<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0\u00a0 [responsivevoice_button rate=&#8221;1\u2033 pitch=&#8221;1.2\u2033 volume=&#8221;0.8\u2033 voice=&#8221;US English Female&#8221; buttontext=&#8221;Story in Audio&#8221;] Babies&#8217; Mysterious Resilience to Coronavirus Intrigues Scientists As the new coronavirus continues to burn through populations, studies are beginning to shed light on its impact on infants. And so far the findings have been promising for parents and researchers alike. The initial data suggest &#8230; <a title=\"Babies&#8217; Mysterious Resilience to Coronavirus Intrigues Scientists\" class=\"read-more\" href=\"https:\/\/aviancetechnologies.com\/blog\/babies-mysterious-resilience-to-coronavirus-intrigues-scientists\/\" aria-label=\"Read more about Babies&#8217; Mysterious Resilience to Coronavirus Intrigues Scientists\">Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":5252,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[27],"tags":[],"class_list":["post-5251","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-science"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Babies&#039; Mysterious Resilience to Coronavirus Intrigues Scientists - Aviance Technologies<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Babies&#039; Mysterious Resilience to Coronavirus Intrigues Scientists - Aviance Technologies\" \/>\n<meta property=\"og:description\" content=\"\u00a0\u00a0 [responsivevoice_button rate=&#8221;1\u2033 pitch=&#8221;1.2\u2033 volume=&#8221;0.8\u2033 voice=&#8221;US English Female&#8221; buttontext=&#8221;Story in Audio&#8221;] Babies&#8217; Mysterious Resilience to Coronavirus Intrigues Scientists As the new coronavirus continues to burn through populations, studies are beginning to shed light on its impact on infants. And so far the findings have been promising for parents and researchers alike. The initial data suggest ... 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